Imaging atherosclerotic plaque inflammation
نویسندگان
چکیده
منابع مشابه
Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography.
BACKGROUND Atherosclerotic plaque rupture is usually a consequence of inflammatory cell activity within the plaque. Current imaging techniques provide anatomic data but no indication of plaque inflammation. The glucose analogue [18F]-fluorodeoxyglucose (18FDG) can be used to image inflammatory cell activity non-invasively by PET. In this study we tested whether 18FDG-PET imaging can identify in...
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Atherosclerosis is a chronic, progressive, multifocal arterial wall disease caused by local and systemic inflammation responsible for major cardiovascular complications such as myocardial infarction and stroke. With the recent understanding that vulnerable plaque erosion and rupture, with subsequent thrombosis, rather than luminal stenosis, is the underlying cause of acute ischemic events, ther...
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Background—Atherosclerotic plaque rupture is usually a consequence of inflammatory cell activity within the plaque. Current imaging techniques provide anatomic data but no indication of plaque inflammation. The glucose analogue [F]-fluorodeoxyglucose (FDG) can be used to image inflammatory cell activity non-invasively by PET. In this study we tested whether FDG-PET imaging can identify inflamma...
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OBJECTIVE Lipids are central to the development of atherosclerotic plaques. Specifically, which lipids are culprits remains controversial, and promising targets have failed in clinical studies. Sphingolipids are bioactive lipids present in atherosclerotic plaques, and they have been suggested to have both proatherogenic and antiatherogenic. However, the biological effects of these lipids remain...
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Inflammation drives atherosclerotic plaque progression and rupture, and is a compelling therapeutic target. Consequently, attenuating inflammation by reducing local macrophage accumulation is an appealing approach. This can potentially be accomplished by either blocking blood monocyte recruitment to the plaque or increasing macrophage apoptosis and emigration. Because macrophage proliferation w...
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ژورنال
عنوان ژورنال: Nature Clinical Practice Cardiovascular Medicine
سال: 2008
ISSN: 1743-4297,1743-4300
DOI: 10.1038/ncpcardio1160